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キーワード:
synthesis design; chiral resolution; quaternary ammonium salt; chiral phase-transfer catalyst; asymmetric catalysis
要旨:
We report the synthesis of a novel spirocyclic quaternary ammonium salt that possesses axial chirality. Enantiopure material was obtained by fractional crystallization of the corresponding (R,R)-tartrate salt. Application of this chiral quaternary ammonium salt in phase-transfer catalytic asymmetric alkylation of glycinate Schiff base was examined.
