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Free keywords:
Animals
Biomarkers/metabolism
Humans
Lung Diseases/*metabolism/therapy
*Precision Medicine
Proteome/*metabolism
Proteomics
Rhinitis/metabolism/therapy
Aerd
Copd
allergic rhinitis
asthma
environment
mass spectrometry
personalized medicine
protein biomarkers
respiratory diseases
respiratory proteomics
Abstract:
Respiratory diseases are highly prevalent and affect humankind worldwide, causing extensive morbidity and mortality with the environment playing an important role. Given the complex structure of the airways, sophisticated tools are required for early diagnosis; initial symptoms are nonspecific, and the clinical diagnosis is made frequently late. Over the past few years, proteomics has made high technological progress in mass-spectrometry-based protein identification and has allowed us to gain new insights into disease mechanisms and identify potential novel therapeutic targets. This review will highlight the contributions of proteomics toward the understanding of the respiratory proteome listing potential biomarkers and its potential application to the clinic. We also outline the contributions of proteomics to creating a personalized approach in respiratory medicine.
